Blake took advantage of a false-start from the defending champion Usain Bolt to crowned himself champion in Daegu, South Korea with an impressive 9.92 seconds run in a -1.4 m/s headwind.
Powell, on the other hand, was forced to pull from the championships because of a groin injury, but trained everyday throughout the nine-day championships and is said to be OK to race.
The former world record holder had missed being a member of the Jamaican side, anchored by Bolt, which broke the 4x100m relay world record.
The team of Nesta Carter, Michael Frater, Blake and Bolt clocked 37.04 secs to erased the previous mark of 37.10 secs, set at the Beijing Olympics.
Powell ran anchor at that time.
Carter and Frater will also face the starter’s gun in Zurich.